By developing new synthetic methods and strategies we can exploit previously inaccessible tools for light-regulated technologies.
Tetra-ortho-methoxylated azobenzenes have been a coveted goal with many previous syntheses reported. However, their limited scope and generally low yields have hampered a more widespread use.
Our new synthetic approach is compatible with a wide variety of functionalities and furnishes the desired tetra-ortho-methoxylated azobenzenes in synthetically useful yields (up to 99%!).
A robustness test demonstrate their superior compatibility with Solid Phase Peptide Synthesis (SPPS) methods that will enable the preparation of visible light operated peptides by SPPS.